Oral Anticoagulants
Drugs affecting the hematopoietic system can be categorized three classes: oral anticoagulants such as warfarin, antiplatelets such aspirin, and hematopoietic growth factors such as filgrastim. Oral anticoagulants inhibit the synthesis of vitamin K-dependent clotting factors X, IX, VII, and II. Antiplatelets inhibits cyclooxygenase, interferes with platelet aggregation; reduces platelet aggregation by inhibiting adenosine diphosphate pathway; protease-activated receptor-I antagonist, inhibits thrombin. Hematopoietic growth factors stimulate erythropoiesis and is used for the treatment of anemia; stimulate granulocyte formation and is used for neutropenia secondary to bone cancer and chemotherapy (Woo &Robinson, 2020).
